Friday, March 28, 2014

Environmental Exposures and the Risk for Alzheimer DiseaseCan We Identify the Smoking Guns?

Over the past 3 decades, the focus on the molecular pathogenesis of Alzheimer disease (AD) has led to remarkable advances in our understanding of the emergence of symptoms and the course of the disease.1 Biomarkers derived from growing knowledge of the pathobiology have enabled identification of amyloid plaques in both symptomatic and cognitively normal individuals,2 the latter potentially identifying a population at high risk for dementia. About 20 genes have been identified as being associated with increased or decreased risk for late-onset AD (LOAD).3 Most of these linked genes have been identified by genomewide association studies and meta-analyses.3 Each new gene linked to LOAD fills in another gap in our understanding of AD pathogenesis and also serves as a new potential therapeutic opportunity.

Continue Learning:

No comments: